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  Antigen antibody reactions

Antigen antibody reactions:

The interaction of an antibody molecule and antigen determinant is termed as immune complex or antigen - antibody complex. Several factors that are affecting antigen-antibody complex. Specificity antibody to join with only one type of antigen, Binding site of antigen and antibody ( epitope and paratope), Affinity (attraction of Ag- Ab binding ), Binding forces of antigen and antibody – closeness among the antigen and antibody and intermolecular forces, and Avidity (combining capacity of heterogenous antibodies along with multivalent antigen).

The first interaction of an antigenic determinant (epitope) along with its consequent antigen binding site on an antibody is termed as a primary antigen- antibody reaction. The primary antigen-antibody reactions are fast reaction, not dependent on electrolytes and not visible. If the primary antigen- antibody reaction is followed through the aggregation of antigen antibody complexes into macroscopically visible clumps is termed as the secondary antigen-antibody reaction and this aggregation phase might take hours today to arrive at maximum. The two visible reactions are termed as precipitation and agglutination.

 

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