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  Clinical Manifestations

Clinical Manifestations:

Meningitis is the major form of the disease however initially it causes infection in lungs.

Pathogenesis:

The organism enters into the body via inhalation and reaches deep into the lung. The disease is more general in men than women. A mild pulmonary infection is the commonest type of cryptococcosis. There are no clear diagnostic features in symptomatic pulmonary infection. Lesions are made, some might heal and some might become enlarged and encapsulated. An acute pneumonic kind of disease has also been explained.

Meningeal form of cryptococcosis might take place in healthy individuals also however it takes place in patients with abnormalities of the lymphocyte function. Approximately 3 to 20 percent of individuals with AIDS build up cryptococcosis. Initially chronic meningitis or meningoencephalitis develops, with headache and low grade fever pursued by changes in mental state, anorexia, visual disturbances and lastly coma. The disease might last from a few months to numerous years and is fatal always unless treated. It generates chronic meningeal form in AIDS patients. Even although a disease of the CNS, it generates lesions on the skin, mucosa, viscera and bones. At times it resembles tuberculosis and it seldom generates lesions on the skin and bones without any proof of the infection.

Crytpcoccus neoformans causes cryptococcosis that is a disease of CNS.

 

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