Transamination:
The procedure of transfer of an amino group to an α-keto acid from an amino acid, resultant in the creation of a new amino acid and keto acid is termed as transamination. Other words, it is deamination of an amino acid, coupled along with amination of a keto acid.
Transamination is catalyzed via transaminases/aminotransferases along with pyridoxal phosphate functioning like a coenzyme. There are 2 active transaminases in tissues, catalyzing interconversions. They are as follow:
1. Aspartate aminotransferase (AST) is also termed as Glutamate- oxalo acetate transaminase (GOT)
2. Alanine aminotransferase (ALT) is also termed as Glutamate- pyruvate transaminase (GPT)1. AST:
2. ALT:ALT catalyses the transmission of NH2 group from glutamate to pyruvate, resultant in the creation of α -ketoglutaric acid and alanine.
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