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  Important products derived from cholesterol

Important products derived from cholesterol:

In the body cholesterol is transformed into various other types of biologically significant steroids that are bile acids, bile salts and Vitamin D.

Synthesis of Bile Salts from Bile acids:

Bile acids are of two kinds that are

1. Primary bile acids
2. Secondary bile acids

Primary bile acids involve cholic acid and chenodeoxy cholic acid while the secondary bile acids involve deoxycholic acid and lithocholic acid.

Importance:

Bile acids are C24 steroids, detergent type compounds which are in the intestine accountable for the emulsification and absorption of lipids.

Bile salts:

In the liver Cholic acid is conjugated with either glycine or taurine via peptide linkages creating the bile salts glycocholic acid and tauro- cholic acid correspondingly. They combine along with sodium and potassium available in the bile and make water soluble alkaline bile salts that are sodium glyco- cholate and sodium taurocholate correspondingly.

Importance:

1) Bile salts are the digestion promoting components of bile.
2) They lower surface tension and so can emulsify fats.
3) They as well activate lipases.

Vitamin D:

Vitamin D is generated through irradiation of 7-dehydrocholesterol in the skin and in the kidney.

Importance:

Vitamin D is a derived of cholesterol and the precursor of para thyroid hormone that regulates calcium and phosphate metabolism in vertebrates.

 

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