From non-carbohydrate precursors the synthesis of glucose is termed as gluconeogenesis. The main site of gluconeogenesis is liver. It generally takes place while the carbohydrate in the diet is not sufficient to meet the demand in the body; along with the intake of protein rich diet and at of starvation time, while tissue proteins are split to amino acids.

Gluconeogenesis and glycolysis:

Gluconeogenesis and glycolysis are opposite metabolic pathways and share some enzymes. In gluconeogenesis pyruvate is transformed to glucose while in glycolysis, glucose is transformed to pyruvate. Though, gluconeogenesis is not accurate reversal of glycolysis.

There are 3 necessarily irrevesible steps in glycolysis that are


In gluconeogenesis those three reactions are bypassed/substituted via the following news ones.



                                                            Diagram: Gluconeogenesis and Glycolysis


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