Reactions of gluconeogenesis

Reactions of gluconeogenesis:

1. The creation of phosphoenol pyruvate starts with the carboxylation of pyruvate at the expense of ATP (Adenosine Tri-Phosphate) to create oxalo acetate.

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Oxaloacetate is transformed to phosphoenolpyruvate via phosphorylation with GTP, accompanied through a instantaneous decarboxylation.

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2. Fructose 6-phosphate is created from fructose 1, 6-diphosphate via hydrolysis and the enzyme fructose 1, this reaction catalysed by 6-diphosphatase.

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3. Glucose is created through hydrolysis of glucose 6-phosphate catalysed via glucose 6-phosphatase.

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Gluconeogenesis of amino acids:

Amino acids that could be transformed to glucose are known as glucogenic amino acids. Several of the glucogenic amino acids are transformed to the intermediates of citric acid cycle either via transamination/deamination.

Gluconeogenesis of Propionate:

Propionate is a main source of glucose in ruminants, and comes into the main gluconeogenic pathway by the citric acid cycle after conversion to succinyl COA.


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