Epistasis:

The pioneer work of Gregor Johann Mendel appeared to imply that each character was determined by a single factor or determiner or in other terms a pair of genes influenced one trait. Afterward work by geneticists led to the idea that a character need not essentially be due to the action of a single factor however might also be due to the action of numerous factors. Such hereditary units or factors are now termed as genes.

Gene Interaction:

The genes interacting to influence a single trait, when present on various chromosomes will exhibit independent assortment and no interference among the effects of various genes. The situation where one pair of genes reverses or restrains the effect of the other pair of genes by causing the modification of the normal phenotype is termed as gene interaction.

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