Termination of polypeptide chain

Termination of polypeptide chain:

The completion of polypeptide chain is termed as Termination. Through termination, a polypeptide chain is completed and released. The polypeptide chain is finished, while the ribosome arrives at the 3 end of mRNA.

The 3' end consists of stop codons / termination codons. They are:
1. UAG or
2. UAA or
3. UGA.

Termination is helped through the terminating protein issues. From the ribosome terminated polypeptide chain is released.


                                                Diagram: The ribosome reaches the termination or stop codon

Later than the release of polypeptide chain, the 70s unit disconnects into 50s and 30s sub-units. These subunits are once again employed in the creation of other initiation complex.


                                                              Diagram: Termination of translation
After translation the polypeptide chain that is released is inactive. It is processed to build it active. Within the processing the initiating amino acid methionine is eliminated. Together with methionine some more amino acids are separated from the N-terminal of the polypeptide. The processing is performed via deformylase and amino peptidase. This processing is known as post translational modifications.


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