Glucagon:
Glucagon, secreted by alpha cells of the pancreas is a polypeptide hormone with 29 amino acids remainder.
Physiological actions of glucagon:
The main function of glucagon in the body is to raise the blood glucose level by glycogenolysis in the liver. As it increases the blood sugar level it is also termed as Hyperglycemic hormone. The second significant function of glucagon is the gluconeogenesis in the liver in which the amino acids are utilized as substrates. It encourages lipolysis and the discharge of fatty acids in the adipose tissues. The raised fatty acid oxidation leads to the ketogenesis. Glucagon also stimulates the myocardial contractility. Glucagon exerts a direct effect on the kidneys and accelerates the renal plasma flow and glomerular filtration rate. A proper balance among insulin and glucagon production is essential to sustain proper blood glucose level.
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