Introduction to Fischer Projection Formulas
On a two-dimensional surface the problem of drawing 3-D configurations, like a piece of paper, has been a long-standing concern of chemists. The hatched and wedge line notations we have been employing are effective, but when applied to compounds having many chiral centers, it can be troublesome. As part of his Nobel Prize-winning research on carbohydrates, the German chemist Emil Fischer devised a simple notation i.e. still extensively used. The four bonds to a chiral carbon make a cross with the carbon atom at the intersection of the vertical and horizontal lines in a Fischer projection drawing. Toward the viewer (forward of the stereogenic carbon) the two horizontal bonds are directed. The two vertical bonds are directed behind the central carbon that is away from the viewer. Because this is not the general method in which we have viewed this type of structures, how a stereogenic carbon positioned in the common two-bonds-in-a-plane orientation ( x-C-y define the reference plane ) is rotated into the Fischer projection orientation (the far right formula) the following pictures displayed. When writing Fischer projection formulas it is significant to remember these conventions. Because the horizontal bonds toward the viewer and the vertical bonds extend away from the viewer, within the plane a Fischer structure may only be turned by 180º, So maintaining this relationship. The structure must not be flipped over or rotated by 90º.
In the above picture, the resulting formula describes (R)-(-)-lactic acid, if x = CO2H, y = CH3, a = H & b = OH. The mirror-image formula, where x = CO2H, y = CH3, a = OH & b = H, would, certainly, represent (S)-(+)-lactic acid.
The stereoisomers of 2-methylamino-1-phenylpropanol are drawn in the following manner by using the Fischer projection notation. Note: it is customary to set the longest carbon chain as the vertical bond assembly.
In his carbohydrate studies, the value of this notation to Fischer is evident in the picture. There are eight stereoisomers of 2, 3, 4, 5-tetrahydroxypentanal, a set of compounds considered as the aldopentoses. Because in this constitution there are three chiral centers, we should suppose a maximum of 23 stereoisomers. These eight stereoisomers contain four sets of enantiomers. The four stereoisomers that result will be diastereomers if the configuration at C-4 is kept constant (R in the examples shown here). Fischer formulas for these isomers, that Fischer entitled as the "D"-family, are displayed in the diagram. Each of these compounds has an enantiomer that is a member of the "L"-family so, as supposed; there are eight stereoisomers in all. Find out whether a chiral carbon is R or S may appear not easy while using Fischer projections, but it is in fact quite simple. If the lowest priority group (generally hydrogen) is on a vertical bond, configuration is given directly from the relative positions of the three higher-ranked substituents. If the group which have the lowest priority is on a horizontal bond, the positions of remaining groups give the wrong answer (you are in looking at the configuration from the wrong side), so you just reverse it.
The aldopentose structures displayed above in the direction are all diastereomers. A more selective phrase, epimer, is used to designate diastereomers that different in configuration at only one chiral center. So, arabinose and ribose are epimers at C-2, and lyxose and arabinose are epimers at C-3. Though, xylose and arabinose are not epimers, since their configurations different at both C-2 and C-3.
Email based Fischer Projection Formulas Homework Help -Assignment Help
Tutors at the www.tutorsglobe.com are committed to provide the best quality Fischer Projection Formulas homework help - assignment help. They use their experience, as they have solved thousands of the Fischer Projection Formulas assignments, which may help you to solve your complex Fischer Projection Formulas homework. You can find solutions for all the topics come under the Fischer Projection Formulas. The dedicated tutors provide eminence work on your Organic Chemistry homework help and devoted to provide K-12 level Chemistry to college level chemistry help before the deadline mentioned by the student. Fischer Projection Formulas homework help is available here for the students of school, college and university. TutorsGlobe assure for the best quality compliance to your homework. Compromise with quality is not in our dictionary. If we feel that we are not able to provide the homework help as per the deadline or given instruction by the student, we refund the money of the student without any delay.
Qualified and Experienced Fischer Projection Formulas Tutors at www.tutorsglobe.com
Tutors at the www.tutorsglobe.com take pledge to provide full satisfaction and assurance in Fischer Projection Formulas homework help. Students are getting Chemistry homework help services across the globe with 100% satisfaction. We value all our service-users. We provide email based Fischer Projection Formulas homework help - assignment help. You can join us to ask queries 24x7 with live, experienced and qualified Chemistry tutors specialized in Fischer Projection Formulas.
Electrical Properties Associated with Rocks tutorial all along with the key concepts of Electric Current Methods, Resistivity and Conductivity, Electrical resistivities of rocks and minerals, Apparent resistivity, Overburden effects
Particle in One Dimensional Box Problem tutorial all along with the key concepts of Schrödinger wave equation, Orthogonal and Orthonormal Wave Functions, Free electron model
there are three major components of the cpu that are as follow - arithmetic-logic unit (alu), control unit (cu), on-board cache memory.
tutorsglobe.com fungi assignment help-homework help by online infections tutors
tutorsglobe.com translocation types assignment help-homework help by online translocation of solutes tutors
Opt for our first-class Biostatistics Assignment Help service and enhance your grades with 24x7 support of PhD experts at fair prices.
Theory and lecture notes of spherical Flow of Economic Activity all along with the key concepts of Spherical flow of economic activity, circular flow, Gross Domestic Product, Economists. Tutorsglobe offers homework help, assignment help and tutor’s assistance on spherical Flow of Economic Activity.
grab the chance to score maximum grades with superb electrical engineering assignment help at reasonable price range.
tutorsglobe.com external economies of scale assignment help-homework help by online external economies tutors
tutorial all along with the key concepts of definition to the gravity methods, instrumentation, data acquisition, data processing, data analysis and interpretation, micro-gravity monitoring
Bacteria tutorial all along with the key concepts of Features of Bacteria, Growth and Reproduction of bacteria, Feeding and Nutrition of bacteria.
Move ahead with first-class Project Management Assignment Help service to score top grades at competitive prices!
tutorsglobe.com infections due to salmonella assignment help-homework help by online salmonella tutors
www.tutorsglobe.com offers Hour to Hour or 100% Bonus Plan homework help, assignment help, case study, writing homework help, online tutoring assistance by accounting tutors.
density tutorial all along with the key concepts of Concept of density, Mass of the Body, Volume of a Body, Volume of Regular Objects, Volume of Irregular Objects, Density of Mixtures
1932267
Questions Asked
3689
Tutors
1490465
Questions Answered
Start Excelling in your courses, Ask an Expert and get answers for your homework and assignments!!