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  Pathogenesis of HIV

Pathogenesis:

The typical course of HIV infection’s duration is around ten years. There are different phases of HIV infection involving primary infection, dissemination of virus to lymphoid organs, induction of HIV expression, clinical latency, clinical disease & death. The duration between main infection and progression to clinical disease averages around10 years. Death generally takes place within 2 to 5 years after the onset of clinical symptoms.

Clinical manifestations:

According to the Center for Disease Control, (i.e., in USA) the HIV infection and its squeal are categorized into four classes:

Group I – Acute HIV infection or seroconversion illness
Group II – Clinical latency or asymptomatic
Group III – Persistent generalized lymphadenopathy
Group IV – A – Constitutional disease

B – Neurologic disease
C – Secondary infectious disease
D – Secondary cancers
E – Other conditions

 

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