Pathogenesis:
The infectious dose is supposed to pass via the stomach and pylorus. Then invasion of epithelium occurs in small bowl. The bacteria penetrate the cells devoid of causing cellular disruption and pass via to the lamina propria. Here the bacteria are not sufficiently contained and spread to mesenteric lymph nodes. Through the way of lymphatic system and the thoracic duct, they reach the bloodstream, giving mount to a transient and generally symptomless prime bacteraemia. They settle largely in liver, spleen, and bone marrow and are constrained for the enduring incubation period. At the ending of this interval, multiplication of the organisms gives mount to a secondary and persistent bacteremia all along with the signs and symptoms of the disease. Bacteria then pour into the bowl from the biliary tract. The mesenteric nodes stay infected from the beginning however the intestinal epithelium might be cleared apart from at the lymphatic aggregates.
Figure: Pathogenesis of typhoid fever
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