Hepatitis D (Delta Agent):
It is a defective virus that needs Hepatitis B as a helper virus in order to replicate. Infection therefore only takes place in patients who are already infected with Hepatitis B. The virus particle 36 nm in diameter encapsulated with HBsAg, derived from HBV delta antigen is related with virus particles ssRNA genome.
The Complications of Hepatitis D might comprise: Liver failure, Hepatocellular carcinoma Autoimmune manifestations, frequently comprising smooth muscle antibodies and antinuclear antibodies.
Clinical Features:
HDV raises the severity of liver disease in Hepatitis B carriers.
The routes of transmission of hepatitis D are identical to those for hepatitis B. The infection is very largely restricted to persons at high risk of hepatitis B infection, specifically injecting drug users and persons obtaining clotting factor concentrates. Globally more than 15 million people are co-infected. Hepatitis D is very rare in most developed countries, and is mainly related with intravenous drug use.
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