Non-competitive Inhibition:
In this kind of inhibition no competition takes place among the substrate and the inhibitor and the inhibitor comprises no structural resemblance with the substrate and it binds along with the enzyme at a place that other than the active site. Because I and S may combine at dissimilar sites, creation of both EI and ESI complexes occurs. The enzyme is inactivated while inhibitor is bound, whether the substrate is exists or not exist. Non competitive inhibition in contrast to competitive inhibition cannot be overcome through increasing substrate concentration. For instance several heavy metal ions like Ag2+, Hg2+, Pb2+ inhibit the activity of a variety of enzymes. Urease can be inactivated via any one of these metal ions.
Diagram: Non-competitive inhibition
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