Question: Ms. Smith informs you that she is a very busy, active woman and "does not have time to be coming back to the clinic all the time." She also has a phobia of needles. She has a creatinine clearance of 62 and serum creatinine 1.1. With this information in mind, what anticoagulant therapy would you initiate for Ms. Smith? Provide exact dosing and a rationale for your drug choice.