Problem: What is the Theoretical Framework of the article? Background/Objectives: Cultural diversity in healthcare settings is rapidly increasing, posing complex ethical and communication challenges for nurses. Competence in navigating cultural differences, alongside ethical sensitivity, is essential to delivering patient-centered care. This study aimed to examine the relationship between nurses' cultural competence-measured as transcultural self-efficacy-and their knowledge, attitudes, and practices concerning healthcare ethics in primary care settings in Greece. Methods: A cross-sectional study was conducted with 492 nurses using validated Greek versions of the Transcultural Self-Efficacy Tool (TSET-Gr) and the Nurses' Ethics Questionnaire (NEQ-Gr). Descriptive and inferential statistics were used to assess correlations and predictive relationships between demographic variables, cultural self-efficacy subscales, and ethical constructs. Results: Nurses demonstrated moderate to high levels of cultural self-efficacy and ethical sensitivity. Affective self-efficacy was the highest-rated subscale and showed strong positive associations with ethical knowledge (r = 0.27, p < 0.001) and ethical attitudes (r = 0.23, p < 0.001). Multivariable linear regression analysis revealed that higher educational attainment significantly predicted both practical (b = 0.12, p = 0.045) and affective self-efficacy (b = 0.15, p = 0.002), as well as better ethical knowledge and attitudes. Need Assignment Help?