How pathogenic affect defense systems of mucous membranes, Biology

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How pathogenic affect defense systems of mucous membranes

Problem

The human body is designed with a number of systems to defend from pathogenic microorganisms.

1. You have discovered a pathogenic microorganism which is able to damage human cellular tight junctions, how would this affect the defense systems of mucous membranes?

2. What role could your own microbiome play in helping to defend from this pathogenic microorganism?

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