Problem
You were introduced to the causes and characteristics of cancer which included information on some of the main players of this disease. This assignment will assess your ability to construct a logical essay-style response concerning these characteristics and pathways. It will also assess your ability to interpret the findings presented in the assigned research articles in the Learn section (Read: Hallmarks of Cancer - The Next Generation; Read: Telomerase Modulates Wnt Signalling by Association with Target Gene Chromatin).
Instructions
Compose a paragraph-style response for one of the essay topics listed below.
A. Excessive angiogenesis and reduced apoptosis are two of the six characteristics that define cancerous tumors. Discuss how developing treatments for these two conditions might prevent the development of cancer altogether from pre-malignant tumors.
B. Describe how p53 plays a role in both cell cycle arrest and in apoptosis.
C. According to the research article: "Telomerase Modulates Wnt Signalling by Association with Target Gene Chromatin," how did the authors determine that TERT, Brg1, and beta-catenin were all part of the same protein complex on TCF sites in vivo? Describe the assay used to determine this.