Adverse effects of Tenofovir disoproxil fumarate
The most common adverse effects have been nausea, vomiting and diarrhea. Renal failure, including a Fanconi-like syndrome, has been reported; tenofovir dosage must be decreased in patients with renal failure. In vitro studies suggest that mitochondrial toxicity with tenofovir may be less than with other NRTIs, but fatal lactic acidosis has been reported.