Tenofovir disoproxil fumarate (TDF, Viread)
Tenofovir DF is the only nucleotide RTI available for treatment of HIV. It is a prodrug of tenofovir, a potent inhibitor of HIV replication. Tenofovir DF is given once daily and is generally well tolerated. It is effective as part of initial HIV therapy and has activity against some HIV strains that are resistant to other NRTIs. It is available alone or in combination with emtricitabine (Truvada). Tenofovir should not be used in three-drug combinations with abacavir/lamivudine or didanosine/lamivudine because of high rates of virologic failure. Tenofovir is also active against HBV, even strains that are resistant to lamivudine.