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  Severe Combined Immunodeficiency

Severe Combined Immunodeficiency (SCID):

This is an enormously rare inherited disease affecting kids. The gene for the disease is termed as ADA (i.e., Adenine deaminase) is situated on chromosome 20. The children suffer from syndrome wholly lack the immune defense mechanism against infection due to quick death of all white blood cells. SCID is also termed as Bubble Boy Syndrome. The baby is kept in a sterile bubble. Unless provided bone marrow transplant, the child’s life period is short lived.

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What causes SCID?

SCID is a class of inherited disorders. Most of the genetic defects can cause SCID. Such defects decrease the capability of white cells in the blood to fight with infection.
   
What are the symptoms of SCID?

Symptoms of SCID generally become apparent in the first year. The following are the most general symptoms of SCID. Though, each child might experience symptoms differently. Symptoms may comprise:
   
1) numerous, severe, and/or life-threatening infections which are not simply treated and do not respond to medications (as they would in children without SCID), comprising the following:

  • pneumonia - infection of the lungs.
  • meningitis - infection of the brain.
  • sepsis - infection in the bloodstream.


2) other infections, comprise the following:

  • chronic skin infections
  • yeast infections in the mouth and diaper area
  • diarrhea
  • infection of the liver

 

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