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  Bioinformatics

Bioinformatics:

Definition:

Bioinformatics deals with the maintenance and creation of databases of biological information like the gene sequences, nucleic acid and protein sequences. It has its own applications in gene therapy, drug designing, diagnostics, crop improvement, biochemical processes and so on. It includes the data analysis or formation of electronic databases on genomes and protein molecules.

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History of Bioinformatics:

From the starting of the post Mendelian’s period, genetic principles propounded by different geneticists have exposed the functional behavior of discrete hereditary particles termed as the genes, in the expression of different morphological (i.e., phenotypical) and biochemical behavior of organisms. During the last three decades, the progression in molecular biology, the invention of computers, ultra growth in scientific methodologies and introduction of instrumentation at nano stage, have paved the manner for the origin of bioinformatics.

The beginning discoveries like the amino acid sequence of bovine insulin (in 1950s), nucleic acid sequence of yeast alaine tRNA with 77 bases (in 1960s); X-ray crystallographic structure of protein, build up the basis and original databases for data entries and file creation. With further progress made in computational methods, employing quick search algorithms (i.e., BLAST) with hundreds of command options and input formats, the birth of bio-informatical science has been prepared.

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