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  Processing of endogenous antigens

Processing of endogenous antigens:

Endogenous antigens are generated within the cell as in viral infection or the ones that are generated as an outcome of modified self antigens.

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Figure: Cleavage of endogenous antigen

Such antigens are cleaved in proteosomes. Fragments are taken out by protein 2/7. Delivered to TAP1 and TAP2 (i.e., transport associated proteins) Peptide binds to MHC class I molecule with β2 microglobulin.

27_peptide.jpg

 Figure: Peptide or MHC complex with TAP pass via Golgi system. They emerge on the surface of cells to represent the antigen to T cells.

 

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