Hepatitis C:
The main cause of parenterally transmitted non A non B hepatitis. It belongs to the family of Togaviridae. It has an ssRNA genome and does not raise in cell culture, however can infect Chimpanzees.
Pathogenesis:
Incubation period is 6 to 8 weeks. It causes a gentle form of acute hepatitis than does hepatitis B. However 50% individuals build up chronic infection, following exposure. Main complications are chronic liver disease and Hepatocellular carcinoma. It is endemic in most of the countries and prevalent globally.
Transmission of HCV is through blood transfusions, organ donation, blood products, and by intravenous drug abusers.
The method of community acquired infection is not clear. The other mode of transmission is via sexual intercourse.Laboratory Diagnosis:
1) Serology:
Reliable serological tests contain only recently become available. Detection of HCV-specific IgG points out exposure, not infectivity.
2) PCR perceives viral genome in patient’s serum.
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