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  Cholesterol Biosynthesis

Cholesterol Biosynthesis:

Cholesterol is an animal sterol that takes place either free or like fatty esters. In the bile duct when it was first isolated from human gallstones deposited, it is termed as cholesterol. Cholesterol is made up of 1, 2-cyclopentanoperhydrophenanthrene ring system. Even though cholesterol is an necessary compound for life for the synthesis of hormones, bile acids and vitamin D, it is not essential to supply it in the diet since it can be synthesised in the cell from amino acids, acetyl CoA Carbohydrates, fatty acids and glycerol that gets transformed to Acetyl CoA can as well serve like a source for cholesterol synthesis. The liver plays an important role in the cholesterol metabolism that accounts for 90% of the whole endogenic cholesterol and its esters.

A man weighing 70 kg consists of approximately 140 grams of cholesterol. The cholesterol concentration of blood in human is approximately between 150 to 250 mg per 100 ml, being distributed uniformly between the cells and the plasma. The half life of cholesterol is approximately 8 to 12 days.

983_structure of cholestrol.jpg

                                                                    Diagram: Structure of Cholesterol

 

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