--%>
Assignment Help - homework help

  Biosynthesis of cholesterol

Biosynthesis of cholesterol:

Significant intermediates of cholesterol Biosynthesis and enzymes included.

1. Formation of acetyl CoA:

A molecule of acetic acid combines along with coenzyme A (CoA) to generate Acetyl CoA in the existence of an enzyme Acetyl CoA synthetase.

2. Formation of acetoacetyl CoA:

Two molecules of acetyl-CoA condense to create an acetoacetyl- CoA molecule, catalyzed via the enzyme “thiolase”.

3. Formation of HMG CoA:

The acetoacetyl-CoA further goes through condensation with one more molecule of acetyl-CoA to create HMG-CoA (3-Hydroxy 3-Methyl Glutaryl-CoA). The enzyme that mediates this reaction is known as HMG- CoA synthetase.

4. Formation of mevalonate:
The HMG-CoA is gets reduced to create mevalonate by NADPH + H+ dependent reductase (HMG-CoA reductase). In the pathway of cholesterol biosynthesis this is the rate limiting enzyme.

5. So mevalonate formed is then transformed to squalene by various steps.

6. Squalene, along with the formation of several intermediates at last gives rise to the end product cholesterol.

2199_biosynthesis of cholestrol.jpg

 

                                                         Diagram: Biosynthesis of Cholesterol

 

Latest technology based Biology Online Tutoring Assistance

Tutors, at the www.tutorsglobe.com, take pledge to provide full satisfaction and assurance in Biosynthesis of cholesterol homework help via online tutoring. Students are getting 100% satisfaction by online tutors across the globe. Here you can get homework help for Biosynthesis of cholesterol, project ideas and tutorials. We provide email based Biosynthesis of cholesterol homework help. You can join us to ask queries 24x7 with live, experienced and qualified online tutors specialized in Biosynthesis of cholesterol. Through Online Tutoring, you would be able to complete your homework or assignments at your home. Tutors at the TutorsGlobe are committed to provide the best quality online tutoring assistance for Biology homework help and assignment help services. They use their experience, as they have solved thousands of the Biology assignments, which may help you to solve your complex issues of Biosynthesis of cholesterol. TutorsGlobe assure for the best quality compliance to your homework. Compromise with quality is not in our dictionary. If we feel that we are not able to provide the homework help as per the deadline or given instruction by the student, we refund the money of the student without any delay.