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Physiological cause of syndrome-cretinism

Explain the physiological cause of the syndrome which is termed as cretinism?

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Cretinism is mainly caused by chronic deficiency of the thyroid hormones (that is, T3 and T4) during babyhood. The chronic hypothyroidism throughout childhood might cause retardation and low stature due to the low basal metabolic rate in a period of life whenever growth and development of mind faculties take place.

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