Question: What is the advantage of administering nitroglycerin sublingually rather than by the oral route? Need Assignment Help? Question Answer a. The sublingual route allows more predictable absorption, resulting in increased serum levels b. The sublingual route bypasses the liver, resulting in increased serum nitroglycerin levels. c. The sublingual route can be used for all types of drugs, thereby increasing drug efficacy d. The sublingual route minimizes systemic adverse effects, increasing safety of the drug