Why are nad+ levels reduced by ethanol intoxication


Problem:

The ability of the human body to catabolize ethanol in alcoholic beverages depeneds on the presence of alcohol dehydrogenase enzymes in liver cells. Ethanol intoxication leads to

(i) a dramatic decrease in NAD+ levels in liver cells and (

ii) a significant reduction in aerobic utilization of glucose.

Required:

Question 1: Why are NAD+ levels reduced by ethanol intoxication?

Question 2: Why is aerobic utilization of glucose (TCA cycle activity) reduced by ethanol intoxication?

Explain thoroughly.

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Biology: Why are nad+ levels reduced by ethanol intoxication
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