Problem: Mr. Jones is being discharged to home with prescriptions for ibuprofen and prn doses of acetaminophen with hydrocodone. What should the nurse reinforce with discharge teaching? Need Assignment Help? Select all that apply. Take ibuprofen with food. Take hydrocodone routinely and ibuprofen only when needed. Constipation is a concern, so increase fluids and fiber. Pain will not improve with time because it is chronic. Hydrocodone has a high use of abuse and misuse.