Problem: An elderly female with terminal cancer has been taking morphine extended-release 100 mg twice daily for several months. When she was initially increased to this dose, she reported acceptable pain relief. However, for the past two weeks, breakthrough pain has increased, and she is not sleeping well. Which of the following could explain why the patient may now need an increased morphine dose? Need Assignment Help? (Select ALL that apply.) A. Increased gut absorption B. Tolerance to the medication Physical withdrawal Addiction E. Worsening of the patient's disease