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What other factors lead to drug resistance what

Patients often become frustrated if their primary care practitioner does not give them an antibiotic when they are sick. They often dread those infamous words, "It is just a virus." Giving an antibiotic for mild infections and viral illnesses leads to drug resistance.

What other factors lead to drug resistance?
What alternatives are there for diseases that become resistant?
How can we help reinforce education to patients about the dangers of drug resistance?

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