Problem:
Question 1: What mechanism is employed by eukaryotic cells to keep their chromosomes from replicating more than once per cycle?
Question 2: The mechanism of DNA replication gives rise to an "end replication problem" for linear chromosomes. Over time, this problem leads to the loss of DNA from the ends of chromosomes. In cells such as yeast, loss of nucleotides during replication is balanced by addition of nucleotides by telomerase. In humans, however, telomerase is turned off in most somatic cells early in development and chromosomes become shorter with each round of replication. Consider one round of replication in a human somatic cell. Draw one pair of daughter chromosomes showing where there is a loss of chromosomal material.
Please read all the questions carefully and answer them.