Problem
Assume this is about the most closely related affected individuals. Consider only mutant alleles for which evidence is provided ,define symbols, draw and label pedigree, use symbols on pedigree to show known genotypes/alleles, show chances on pedigree, label chances in final calculation. if the affected individual is a direct ancestor, then chances will be 1 or ½; if the affected individual is a sibling, there will be a 2/3 chance in calculation.
• Clyde has mild Gaucher and Bonnie's mother has mild Gaucher. What is the chance that a child of Clyde and Bonnie will be affected by Gaucher Disease?
• Anthony has a sister who died of Gaucher Disease while still an infant. Cleopatra had a maternal uncle with Gaucher who died in his teens. What is the chance that Anthony and Cleopatra will have an affected child?
• James had a great-grandmother with a mild case of Gaucher Disease, whereas Lily's father has a sister with mild Gaucher. What is the chance that the child of James and Lily will have mild GD?