Question: When the cytoskeleton signals for a smooth muscle contraction which of the following does not occur. Need Assignment Help? Question options: Myosin is phosphorylated Surface cell receptor activation signals for elevated intracellular Ca2+ to bind to calmodulin. Phosphorylation of actin binding proteins triggers actin polymerization. The Ca2+/calmodulin complex binds to myosin light chain kinase.