What do mirnas and sirnas have in common


Problem:

Question 1: What do miRNAs and siRNAs have in common? What is different about them? What is their effect on gene expression?

Question 2: Why do cell biologists commonly apply siRNAs to cells in culture? What effect does siRNA have on protein expression, and how do they achieve that effect?

Question 3: Why do cells have few E1 ubiquitin-activating enzymes and many E3 ubiquitin ligases?

Question 4: How can a protein's stability change under different cellular conditions??

Question 5: Why would the proteosome not degrade a protein that is poly-ubiquitylated?

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Biology: What do mirnas and sirnas have in common
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