Q. Summarize the cellular and molecular events of bone formation?
The events involved in osseous wound healing at implants recapitulate the events of wound healing. Haemostasis, clot formation, fibrinolysis, formation of loose connective tissue stroma (that supports angeogenesis) & neovascularization. After the establishment of a well vascularised, immature connective tissue, osteogenesis continues by the recruitment, proliferation and differentiation of the osteoblastic cells. Differentiated osteoblast secretes a collagenous matrix and contributes to its mineralization.
The formal matrix surrounds the osteoblastic cells and mineralization of a collagenous rich matrix proceeds towards completion. This cell rich and unorganized bone is called woven bone. The transformation of woven bone to lamellar bone, bone organized to resist physical strain and displaying a Haversian architecture, is another important part of osseointegration.