In what ways are the mechanistic features of trypsin, Chemistry

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In what ways are the mechanistic features of trypsin

1. What geometric constraints are the amide N-H groups of Ser 195 and Gly 193 subject to in trypsin, chymotrypsin, elastase?

2. In what ways are the mechanistic features of trypsin, chymotrypsin, elastase similar? If the mechanisms of these enzymes are similar, what
features of the enzyme active site dictate substrate specificity?

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