Problem: Carcinogenesis is a multistep process involving initiation, promotion, and progression. This metastatic dissemination takes place in the progression phase where multiple mutations and epimutations are accumulated. Cells become invasive, degrade basement membranes, intravasate, and colonize distant sites (NCI, 2023b). This systemic dissemination represents the highest mortal phase of the cancer process and translates an organ-confined malignancy into a disease of catastrophic clinical repercussions. How to provide a constructive reply. Need Assignment Help?