Question - How is cancer influenced by genetics/genetic background? Why do tumor cells have a greater degree of genetic instability than normal cells? What is the difference between benign and malignant tumors? What is the Warburg effect and how does t helps cancers to grow? What are oncogenes and tumor suppressors are and how they're different? What types of mutations are expected in proto-oncogenes and tumor suppressors? What is the minimum number of mutation events that would convert a proto-oncogene to an oncogene or inactive a tumor suppressor gene (don't forget that we have two copies of each gene!)? What are other events that could convert a proto-oncogene into an oncogene (e.g. gene amplification)? What is the difference between driver and passenger mutations in cancer?