How does an observational study differ from randomized trial


Assignment:

Q&A

https://www.uctv.tv/shows/Vitamins-and-Supplements-Less-is-More-30675

Vitamins and Supplements: Less is More: Dr. Jeffrey Tice

This video looks at observational vs randomized trials (RCT) to consider current science on popular supplements. I am only assigning the first hour (start at 6 minutes and listen through 1:04), but the last 30 minutes considers Omega-3s if you are interested).

1. List 3 ideas that were new to you or different than what you expected.

2. How does an observational study differ from a randomized trial and which is more reliable?

3. Compare the information in the video to what you have learn, so far, in the book.

4. When looking at observational studies, who were the people most likely to take supplements?

5. How did the observational data for B-carotene and Vit E differ from the randomized trials? Bjelakovic, JAMA 2007

6. In looking at Clarke's data (Archives IM) published in 2010, what was the affect of B vitamin supplements on homocysteine levels and how did this affect death, cardiovascular events and cancer?

7. What affect does folate (including supplementation or flour fortification) have on specified birth defects?

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Biology: How does an observational study differ from randomized trial
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