Question: What are the Implications for practice? (Not more than 3 sentences) This narrative review demonstrates the complexity of implementing and maintaining the highest-leverage systemic defenses in clinical practice. While barcode technologies are robust systemic defenses that focus on system change, the human component remains a crucial part of the complex human-system interface. Therefore, it is imperative for health care organizations to identify and eliminate the barriers that hinder the intended use of workflows at the system level. Failure to do so may lead to at-risk behavior and the development of workarounds, which can compromise the effectiveness of barcode technologies in preventing MEs. Furthermore, risk management actions should be targeted to identify new types of MEs resulting from changes in the MMU process. Need Assignment Help?