Extracellular signal-regulated kinase (ERK), Focal Adhesion Kinase (FAK) and c-Jun N-terminal kinase (JNK) rol in cell migration and cancer metastasis. The paper must talk about the role of ERK, JNK and FAK in cell migration and in cancer metastasis (the latest findings), the validation studies for each of them and if there are any drugs or any attempt to inhibit them either preclinically or clinically as anti-cancer therapeutic targets (briefly don’t focus on that) And if there are correlation between them and PSA-Ncam should be included in the end.