Question: Asthma is a Type I hypersensitivity reaction due to mediation by IgE antibodies. Allergens and pollutants are often triggers for asthma symptoms; T-helper cells respond to allergens by releasing interleukin, promoting B cells to produce IgE. Eosinophils, mast cells, basophils and macrophages are recruited by the cytokines bathing the airway epithelial cells, causing airway inflammation. IgE interacts with mast cells and degranulation leads to asthma symptoms. Need Assignment Help?