A case-control study looked at association of alcohol use with occurrence of coronary heart disease (CHD). There were 300 participants in study (150 cases and 150 controls). Of the cases, 90 participants drank alcohol; of the controls, 60 participants drank alcohol.
Develop the appropriate 2x2 table, compute and interpret the appropriate measure of association
You suspect that the association between alcohol use and CHD may be confounded by smoking. You gather the following data
|
|
Smokers
|
nonsmokers
|
|
|
CHD NO CHD
|
CHD NO CHD
|
|
alcohol use
|
80
|
40
|
10
|
20
|
|
No alcohol
|
20
|
10
|
40
|
80
|
Compute the appropriate measure of association between alcohol use and CHD in both smokers and non-smokers. Determine whether smoking was the confounder of association. Determine the relationship of alcohol use to CHD after controlling for confounding?