Problem: Assembly of eukaryotic condensin I. The SMC dimer adopts a V-shaped molecule with two coiled-coil arms. The hinge domain is responsible for dimerization, and ATP-binding head domains are located at distal ends of the arms. The kleisin subunit is predicted to bridge the two head domains through an asymmetric binding mode. The two HEAT subunits associate with the central region of the kleisin subunit to form a holocomplex. From Hirano, T. (2016). Condensin-Based Chromosome Organization from Bacteria to Vertebrates. Cell 164: 847-857. Need Assignment Help?