--%>
Assignment Help - homework help

  Von-Gierke’s Disease

Von-Gierke’s Disease:

Von-Gierke’s Disease is one of the groups of rare genetic disorder because of the defect in one or more of the enzymes included in glycogen metabolism leading to excessive growth of glycogen in the tissue particularly in liver, muscle and heart.

The first glycogen storage disease recognized was Von-Gierke’s disease. The occurrence of this disease is one in two lakhs.

Cause:

This was very firstly inherited deficiency recognized to influence liver. In this, the enzyme that is deficient is glucose 6-phosphatase which converts glycogen to glucose 6-phosphate and after that to glucose.

2208_von gierke.jpg


  

                                                          Diagram: Conversion of glycogen to glucose

Symptoms:

Both of the liver cells and cells of renal convoluted tubules are loaded with glycogen. Ketosis and hyperlipidemia are as well available. Glycogen content in the liver can get higher to 15%. Glycogen accumulates as well in kidney. Huge enlargement of the liver, pronounced hypoglycemia in among the meals, failure of blood glucose to increase on administration of glycogen and convulsion are observed in this condition. Because glucose 6-phosphate cannot leave liver cells, there is compensatory raise in glycolysis leading to increased levels of pyruvic acid and lactic acid. The single treatment available is frequent feeding to prevent hypoglycemia in Von- Gierke’s Disease.

 

Latest technology based Biology Online Tutoring Assistance

Tutors, at the www.tutorsglobe.com, take pledge to provide full satisfaction and assurance in Von-Gierke’s Disease homework help via online tutoring. Students are getting 100% satisfaction by online tutors across the globe. Here you can get homework help for Von-Gierke’s Disease, project ideas and tutorials. We provide email based Von-Gierke’s Disease homework help. You can join us to ask queries 24x7 with live, experienced and qualified online tutors specialized in Von-Gierke’s Disease. Through Online Tutoring, you would be able to complete your homework or assignments at your home. Tutors at the TutorsGlobe are committed to provide the best quality online tutoring assistance for Biology homework help and assignment help services. They use their experience, as they have solved thousands of the Biology assignments, which may help you to solve your complex issues of Von-Gierke’s Disease. TutorsGlobe assure for the best quality compliance to your homework. Compromise with quality is not in our dictionary. If we feel that we are not able to provide the homework help as per the deadline or given instruction by the student, we refund the money of the student without any delay.