--%>
Assignment Help - homework help

  Galactosemia

Galactosemia:

Galactosemia is an inherited disorder, where there is inability to convert galactose to glucose in a general way. The incidence of this disease is approximately 1 in 18,000 live births.

Causes:

Enzyme deficiency in galactose metabolic pathway originates the galactosemia. The pathway for translation of galactose to glucose is displayed in the below figure.

2326_galoctosemia.jpg


                                                                Diagram: Metabolism of Galactose

In galactosemia, there is incapability to metabolize galactose that may be caused through the enzyme deficiency of a = galactokinase, b = UDP Galactose 1 - phosphate uridyl transferase.

Symptoms:

The absence of galactose 1-phosphate uridyl transferase is clinically significant. Because of the enzyme defect galactose accumulates in blood and is decreased through aldose reductase in the eye to the corresponding galactitol that causes cataract.

The normal condition is more severe if it is because of a defect in galactose 1 - phosphate uridyl tranferase, because galactose 1-phosphate accumulates and depletes the liver of inorganic phosphate. Finally liver failure and mental deterioration results.

Infants emerge normal at birth but after that they show failure to thrive and become lethargic. They have often vomitting and hypoglycemia. Later than the 2 - 3 months of age the liver might depict fatty infiltration and go ahead to cirrhosis (non functioning of liver cells). Galactosemia at this age is related with mental retardation because of accumulation of galactose and galactose 1-phosphate in cerebral cortex. Thus, the galactosemic child fails to grow up and suffer from liver damage and mental retardation.

 

Latest technology based Biology Online Tutoring Assistance

Tutors, at the www.tutorsglobe.com, take pledge to provide full satisfaction and assurance in Galactosemia homework help via online tutoring. Students are getting 100% satisfaction by online tutors across the globe. Here you can get homework help for Galactosemia, project ideas and tutorials. We provide email based Galactosemia homework help. You can join us to ask queries 24x7 with live, experienced and qualified online tutors specialized in Galactosemia. Through Online Tutoring, you would be able to complete your homework or assignments at your home. Tutors at the TutorsGlobe are committed to provide the best quality online tutoring assistance for Biology homework help and assignment help services. They use their experience, as they have solved thousands of the Biology assignments, which may help you to solve your complex issues of Galactosemia. TutorsGlobe assure for the best quality compliance to your homework. Compromise with quality is not in our dictionary. If we feel that we are not able to provide the homework help as per the deadline or given instruction by the student, we refund the money of the student without any delay.