Comparative Genomics

Question

What are Comparative Genomics and what is the approach to Comparative Genomics?

Answer 1

A) Comparative mapping has been an extremely useful tool for cross-species leverage of information

B) Comparative genomics can be even more powerful

C) It is a time consuming process

D) Databases have the potential to automate much of the work

E) Comparing data from databases is complicated by mismatches in

• DBMS
• Database schemas
• Of course, projects such as Ensembl Genomes may solve such problems

Approaches to Comparative Genomics:

i) Warehousing:

• Genomic data for many species  stored as one large ‘data warehouse’

ii) Middleware:

• Applications
• Templates (e.g. Biomart)
• Ontologies (the Semantic Web)