Problem 1:
(a) Define a prodrug and what are different types of prodrug?
(b) Why is it necessary to design pro-drugs? Use examples of carrier-linked bipartate prodrugs in support of your arguments.
Problem 2: Given a pentapeptide known to contain valine (two residues), leucine (one residue), histidine (one residues) and phenyl alanine (one residue). Then let us assume that by using DNFB and carboxypeptidase we determine that valine and leucine are the N-terminal and C-terminal residues, respectively. What is the partial structure of pentapeptide?
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